产品货号：
Z24246
中文名称：
PPM1A抗体
英文名称：
Anti-PPM1A Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PPM1A Antibody |
| 指标别名 | PP2C ALPHA;PP2CA;PPM1A;PPPM1A;Protein phosphatase 1A;Protein phosphatase IA |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,ELISA |
| 基因名称 | PPM1A |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence of human PPM1A(HAGSQVAKYCCEHLLDHITNNQDFK). |
| 实际分子量 | 42KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Protein phosphatase 1A is an enzyme that in humans is encoded by the PPM1A gene.It is mapped to 14q23.1.The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases.PP2C family members are known to be negative regulators of cell stress response pathways.This phosphatase dephosphorylates,and negatively regulates the activities of,MAP kinases and MAP kinase kinases.It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses.This phosphatase can also dephosphorylate cyclin-dependent kinases,and thus may be involved in cell cycle control.Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53,which leads to G2/M cell cycle arrest and apoptosis.Three alternatively spliced transcript variants encoding distinct isoforms have been described. |
| Uniprot ID | P35813 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | protein phosphatase,Mg2+/Mn2+ dependent 1A |
| 蛋白名全称 | Protein phosphatase 1A |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (ELISA)： 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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